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Correlations between serum testosterone and irisin levels in a sample of Egyptian men with metabolic syndrome;
Inass Hassan Ahmad1, Eman Roshdy Mohamed Mostafa2, Shymaa Abdelhafeez Mohammed3
1Endocrinology Department, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt.
Background:
Metabolic syndrome (MetS) in men is a common problem. Several studies highlight that testosterone deficiency is associated with metabolic disorders that may be explained by "myokines". Irisin is an adipo-myokine that has beneficial metabolic effects.
Aim:
To evaluate serum testosterone in a sample of Egyptian men with MetS diagnosed by NCEP ATP III, and correlate it with serum irisin level.
Methods:
A total of 90 men (60 with MetS and 30 healthy age-matched controls) participated in the study. Testosterone level is estimated by an automated system, Irisin level was measured by ELISA.
Results:
Circulating irisin was positively correlated with serum testosterone and was significantly lower in patients with MetS.
Conclusion:
This study highlights the effect of serum testosterone on irisin formation from skeletal muscle. Recommendations; treatments of MetS may include testosterone supplementation. Further studies are needed to elucidate this association.
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