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Updated: Dec 10, 2025

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
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Antiphospholipid syndrome: Complement activation, complement gene mutations, and therapeutic implications.

Shruti Chaturvedi1, Evan M Braunstein1, Robert A Brodsky1

  • 1Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Journal of Thrombosis and Haemostasis : JTH
|September 4, 2020
PubMed
Summary
This summary is machine-generated.

Antiphospholipid syndrome (APS) involves blood clots and pregnancy issues. Complement inhibition may be a promising therapy for severe APS and catastrophic APS (CAPS) to reduce mortality.

Keywords:
antiphospholipid syndromecomplementeculizumabgeneticsthrombosis

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Area of Science:

  • Immunology
  • Hematology
  • Rheumatology

Background:

  • Antiphospholipid syndrome (APS) is an acquired thromboinflammatory disorder.
  • It is characterized by antiphospholipid antibodies, thrombosis, and/or obstetrical morbidity.
  • Severe APS, known as catastrophic APS (CAPS), has high mortality despite treatment.

Purpose of the Study:

  • To explore the role of complement in APS pathophysiology.
  • To investigate complement inhibition as a therapeutic strategy for severe APS and CAPS.

Main Methods:

  • Review of animal models implicating complement in APS thrombosis.
  • Analysis of human studies confirming coagulation and complement pathway interactions.
  • Examination of germline variants in complement regulatory genes in APS patients.

Main Results:

  • Complement activation via antiphospholipid antibodies contributes to cellular injury and coagulation.
  • Interaction between coagulation and complement pathways is confirmed in APS.
  • Germline variants in complement regulatory genes may increase CAPS risk.

Conclusions:

  • Complement inhibition is a potential therapeutic strategy for severe thrombotic APS and CAPS.
  • Targeting complement may mitigate morbidity and mortality in severe APS.
  • Understanding complement's role is crucial for managing severe APS and CAPS.