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Establishing Serum Reference Ranges for Antihypertensive Drugs
Stine Rognstad1,2,3, Camilla L Søraas3,4, Ola U Bergland2,3
1Department of Pharmacology, Oslo University Hospital.
Therapeutic Drug Monitoring
|September 4, 2020
Summary
Therapeutic drug monitoring (TDM) for hypertension is crucial. Establishing serum reference ranges for antihypertensive drugs aids in optimizing treatment and identifying nonadherence for personalized medicine.
Area of Science:
- Pharmacology
- Clinical Pharmacy
- Hypertension Management
Background:
- Therapeutic drug monitoring (TDM) is key for optimizing pharmacotherapy by measuring serum drug concentrations.
- Current hypertension management often relies solely on blood pressure, failing to control it in about 50% of patients.
- Serum drug levels can identify nonadherence and guide drug selection and dosage adjustments.
Purpose of the Study:
- To establish serum reference ranges for commonly prescribed antihypertensive drugs.
- To support the implementation of TDM in routine clinical practice for hypertension.
- To advance personalized medicine in antihypertensive pharmacotherapy.
Main Methods:
- Identified commonly used antihypertensive drugs from prescription data.
- Conducted a literature review for reported serum drug concentrations and pharmacokinetic parameters.
- Measured serum drug concentrations in patients undergoing antihypertensive treatment.
Main Results:
- Established serum reference ranges for 24 frequently used antihypertensive drugs.
- Utilized three distinct approaches to determine these reference ranges.
- Provided a foundation for interpreting serum drug concentrations in clinical settings.
Conclusions:
- Serum drug concentration measurements, alongside established reference ranges, can identify nonadherence.
- TDM can help tailor individual antihypertensive treatment for better patient outcomes.
- This approach aligns with the principles of personalized medicine for managing hypertension.
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