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Updated: Dec 10, 2025

Orthotopic Aortic Transplantation in Mice for the Study of Vascular Disease
Published on: November 28, 2012
A Confirmed Case of Zoonotic Aortitis and Successful Repair with an Allograft
Prasad V Gade1, Andrew J Witten2, Nehal Ninad2
1Evansville Surgical Associates, Deaconess Health System, Evansville, IN, USA.
Introduction:
Streptococcus equi subspecies zooepidemicus is a β-haemolytic group C streptococcus that is a highly contagious infection in horses and other equines. Streptococcus equi infection of the native human aorta is a rare form of aortitis that has a high mortality owing to rupture. Surgical intervention with debridement and broad spectrum intravenous antibiotics are essential to improve the patient's status.
Report:
In this case study, a 71 year old man with horse contact presented with left groin pain related to S. equi aortitis and mycotic aneurysm. He was successfully treated by excision of the infected abdominal aorta and iliac vessels with a biological graft reconstruction, debridement of the retroperitoneum, and application of antibiotic beads.
Discussion:
Biological grafts have never been reportedly used in group C streptococcus infection of the native aorta, and the patient recovered without sequelae. The promising outcome of this case may provide a framework for future similar cases.

