Related Experiment Video
Updated: Dec 10, 2025

Remote Laboratory Management: Respiratory Virus Diagnostics
Published on: April 6, 2019
AmbuBox: A Fast-Deployable Low-Cost Ventilator for COVID-19 Emergent Care
Zecong Fang1, Andrew I Li2, Hongcheng Wang1,3
1Micro-Nano Innovations (MiNI) Laboratory, Department of Biomedical Engineering, University of California, Davis, CA, USA.
We developed AmbuBox, a low-cost, clinically viable ventilator using readily available AmbuBags. This design is easily manufactured and deployed for mass-casualty events, offering precise control and a long lifespan.
Area of Science:
- Biomedical Engineering
- Medical Devices
- Emergency Preparedness
Background:
- Existing low-cost ventilators often lack precision or ease of use.
- Pandemic and mass-casualty events necessitate rapid deployment of reliable respiratory support.
- Accessibility and affordability are critical factors in global healthcare solutions.
Purpose of the Study:
- To present a novel, low-cost, and clinically viable ventilator design named AmbuBox.
- To address limitations of current low-cost ventilator designs through improved functionality and usability.
- To facilitate rapid production and deployment during public health emergencies.
Main Methods:
- Development of a controllable pneumatic enclosure integrated with standard manual resuscitators (AmbuBags).
- Characterization and validation of a mass-producible prototype using a lung simulator in a bench test setup.
- Detailed documentation of design, operational principles, fabrication, and assembly for local manufacturing.
Main Results:
- A functional AmbuBox prototype was successfully devised, characterized, and validated.
- The design emphasizes ease of installation, operation, and high-precision flow control.
- Component list and fabrication methods are provided for low-cost, rapid production.
Conclusions:
- The AmbuBox represents a promising solution for accessible and rapidly deployable mechanical ventilation.
- Further clinical testing is planned to confirm efficacy in patient care.
- Open-access dissemination of the design supports global manufacturing efforts for emergency needs.
Related Concept Videos
Mechanical Ventilation II: Invasive Ventilation
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Oxygen Delivering System I: Nasal Cannula and Face Mask
Nasal Cannula
A nasal cannula is a lightweight tube split at one end into two prongs and placed in the nostrils. It is typically used to deliver low to medium levels of oxygen.
Suggested flow rate: The suggested flow rate for a nasal cannula typically ranges between 1 and 6 L/min.
Oxygen percentage setting:...
Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
Acute Respiratory Failure-IV
Acute Respiratory Failure-II
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
Acute Respiratory Failure-V
Ensure that patients are monitored continuously for their response to therapy, including changes in...

