Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

12.9K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
12.9K
LTR Retrotransposons03:08

LTR Retrotransposons

19.1K
LTR retrotransposons are class I transposable elements with long terminal repeats flanking an internal coding region. These elements are less abundant in mammals compared to other class I transposable elements. About 8 percent of human genomic DNA comprises LTR retrotransposons. Some of the common examples of LTR retrotransposons are Ty elements in yeast and Copia elements in Drosophila.
The internal coding region of LTR retrotransposons and their mechanism of transposition closely resembles a...
19.1K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

9.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.6K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.2K
3.2K
Overview of Transposition and Recombination02:13

Overview of Transposition and Recombination

18.4K
Transposons make up a significant part of genomes of various organisms. Therefore, it is believed that transposition played a major evolutionary role in speciation by changing genome sizes and modifying gene expression patterns. For example, in bacteria, transposition can lead to conferring antibiotic resistance. Movement of transposable elements within the genetic pool of pathogenic bacteria can aid in transfer of antibiotic-resistant genetic elements. In eukaryotes, transposons can carry out...
18.4K
DNA-only Transposons02:57

DNA-only Transposons

16.6K
DNA-only transposons are called autonomous transposons since they code for the enzyme transposase that is required for the transposition mechanism. Insertion of transposons can alter gene functions in multiple ways. They can mutate the gene, alter gene expression by introducing a novel promoter or insulator sequence, introduce new splice sites, and change the mRNA transcripts produced, or remodel chromatin structure.
The donor site from where the transposon is excised is either degraded or...
16.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ACSA2 is not astrocyte-specific: implications for cell sorting strategies in the rodent brain.

Frontiers in cellular neuroscience·2026
Same author

Combining anti-metabolic treatments with the repurposing of eribulin for glioblastoma: a clinical opportunity?

Translational cancer research·2025
Same author

A versatile and efficient method to isolate nuclei from low-input cryopreserved tissues for single-nuclei transcriptomics.

Scientific reports·2025
Same author

The Actin Cytoskeleton as a Regulator of Proteoglycan 4.

Cartilage·2024
Same author

Highly efficient reprogrammable mouse lines with integrated reporters to track the route to pluripotency.

Proceedings of the National Academy of Sciences of the United States of America·2022
Same author

Determining epigenetic memory in kidney proximal tubule cell derived induced pluripotent stem cells using a quadruple transgenic reprogrammable mouse.

Scientific reports·2022
Same journal

Focadhesin interacts with SALL4 to regulate EGFR signaling and oncogenesis in non-small cell lung cancer.

Biochimica et biophysica acta. Molecular cell research·2026
Same journal

Extracellular matrix stiffness primes the NLRP3-Inflammasome by promoting NLRP3 gene expression via FAK/mTOR/nuclear-actin/SREBP signalling in vascular smooth muscle cells.

Biochimica et biophysica acta. Molecular cell research·2026
Same journal

A putative role for Mrx3 and Fmp10 in regulating yeast mitochondrial acyl-CoA thioesters.

Biochimica et biophysica acta. Molecular cell research·2026
Same journal

Narirutin inhibits inflammation and oxidative stress in osteoarthritis via suppressing AKT/NF-κB signaling.

Biochimica et biophysica acta. Molecular cell research·2026
Same journal

Fibroblasts carrying intermediate C9orf72 hexanucleotide repeat expansions from iNPH patients show changes in energy metabolism but no cell pathologies.

Biochimica et biophysica acta. Molecular cell research·2026
Same journal

SMN haploinsufficiency exacerbates high glucose dialysate-induced peritoneal inflammation and fibrosis via mTOR/NFκB signaling pathway.

Biochimica et biophysica acta. Molecular cell research·2026
See all related articles

Related Experiment Video

Updated: Dec 10, 2025

Real-Time Quantification of the Effects of IS200/IS605 Family-Associated TnpB on Transposon Activity
04:04

Real-Time Quantification of the Effects of IS200/IS605 Family-Associated TnpB on Transposon Activity

Published on: January 20, 2023

2.7K

Long non-coding RNAs and transposable elements: A functional relationship.

Victoire Fort1, Gabriel Khelifi1, Samer M I Hussein1

  • 1Laval University Cancer Research Centre, Canada; Research Center of the CHU of Québec, Laval University, Québec G1R 3S3, Canada.

Biochimica Et Biophysica Acta. Molecular Cell Research
|September 4, 2020
PubMed
Summary
This summary is machine-generated.

Long non-coding RNAs (lncRNAs) regulate gene expression and cellular functions. This review explores how functional domains within lncRNAs, often from transposable elements, contribute to their diverse mechanisms of action.

Keywords:
Long interspersed nuclear elementsLong non-coding RNAsRNA binding proteinsRNA functional domainsShort interspersed nuclear elementsTransposable elements

More Related Videos

RNA Next-Generation Sequencing and a Bioinformatics Pipeline to Identify Expressed LINE-1s at the Locus-Specific Level
11:04

RNA Next-Generation Sequencing and a Bioinformatics Pipeline to Identify Expressed LINE-1s at the Locus-Specific Level

Published on: May 19, 2019

10.3K
Chromatin Isolation by RNA Purification ChIRP
11:09

Chromatin Isolation by RNA Purification ChIRP

Published on: March 25, 2012

87.8K

Related Experiment Videos

Last Updated: Dec 10, 2025

Real-Time Quantification of the Effects of IS200/IS605 Family-Associated TnpB on Transposon Activity
04:04

Real-Time Quantification of the Effects of IS200/IS605 Family-Associated TnpB on Transposon Activity

Published on: January 20, 2023

2.7K
RNA Next-Generation Sequencing and a Bioinformatics Pipeline to Identify Expressed LINE-1s at the Locus-Specific Level
11:04

RNA Next-Generation Sequencing and a Bioinformatics Pipeline to Identify Expressed LINE-1s at the Locus-Specific Level

Published on: May 19, 2019

10.3K
Chromatin Isolation by RNA Purification ChIRP
11:09

Chromatin Isolation by RNA Purification ChIRP

Published on: March 25, 2012

87.8K

Area of Science:

  • Genetics and Molecular Biology
  • RNA Biology

Background:

  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their regulatory roles in gene expression and cellular processes.
  • Investigating lncRNAs is challenging due to low expression levels and a lack of specialized tools.
  • While cellular functions are studied, the precise mechanisms of action for most lncRNAs remain unclear.

Purpose of the Study:

  • To review the diverse functions of lncRNAs.
  • To explore the role of functional domains within lncRNAs, particularly those originating from transposable elements.
  • To connect lncRNA functions with embedded transposable elements.

Main Methods:

  • Literature review of studies on lncRNA functions and mechanisms.
  • Analysis of research highlighting functional domains in lncRNAs.
  • Examination of the origins of lncRNA functional units from transposable elements.

Main Results:

  • lncRNAs exhibit a wide range of cellular functions, including gene expression regulation.
  • Functional domains, analogous to protein domains, are being identified in lncRNAs.
  • A significant portion of these functional domains are derived from transposable elements.

Conclusions:

  • lncRNAs possess functional domains that dictate their mechanisms of action.
  • Transposable elements contribute functional units that are integral to lncRNA activity.
  • Further research into lncRNA domains and their transposable element origins is crucial for understanding their biological roles.