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Related Experiment Video

Updated: Dec 10, 2025

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
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Exploiting nanoscale cooperativity for precision medicine.

Jonathan Wilhelm1, Zhaohui Wang1, Baran D Sumer2

  • 1Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA.

Advanced Drug Delivery Reviews
|September 4, 2020
PubMed
Summary
This summary is machine-generated.

Nature-inspired nanoscale cooperativity enhances drug delivery precision. Ultra-pH-sensitive nanoparticles amplify physiological signals for improved therapeutic outcomes in cancer immunotherapy.

Keywords:
All-or-nothing protonationCancer immunotherapyPhase transitionTumor-targeted drug deliveryUltra-pH sensitive micellespH-activatable drug release

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Drug Delivery

Background:

  • Precise molecular transport is crucial for physiological functions.
  • Conventional nanocarriers lack targeted delivery and controlled release, limiting therapeutic impact.
  • Nature utilizes macromolecular cooperativity for precise molecular delivery.

Purpose of the Study:

  • To propose a design principle for nanomedicine using nanoscale cooperativity and phase transition.
  • To improve therapeutic outcomes by sensing and amplifying physiological signals.
  • To demonstrate the efficacy of ultra-pH-sensitive (UPS) nanoparticles for targeted drug delivery and cancer immunotherapy.

Main Methods:

  • Development of ultra-pH-sensitive (UPS) nanoparticles utilizing all-or-nothing protonation cooperativity.
  • Exploitation of micelle assembly/disassembly for enhanced dose accumulation and rapid drug release in acidic microenvironments.
  • Application of a single polymer composition for cytosolic delivery of tumor antigens and STING activation in dendritic cells.

Main Results:

  • UPS nanoparticles demonstrated increased dose accumulation and rapid drug release in acidic tumor microenvironments.
  • Successful cytosolic delivery of tumor antigens was achieved, activating stimulator of interferon genes (STING).
  • Enhanced activation of lymph node-resident dendritic cells for cancer immunotherapy.

Conclusions:

  • Nanoscale cooperativity and phase transition offer a powerful strategy for precision nanomedicine.
  • UPS nanoparticles can effectively target acidic tumor microenvironments and enhance drug release.
  • This approach holds significant promise for advancing cancer immunotherapy and precision medicine.