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Updated: Dec 10, 2025

Preparation and Characterization of C60/Graphene Hybrid Nanostructures
Published on: May 15, 2018
Physicochemical properties, biological activity and biocompatibility of water-soluble C60-Hyp adduct
Anatolii A Meshcheriakov1, Gleb O Iurev2, Michail D Luttsev3
1Institute of Chemistry, Saint Petersburg State University, Universitetskii Prospect 26, Saint Petersburg, 198504, Russia.
Abstract:
Amino acid adducts of light fullerenes have a potential of application in a variety of fields of biomedicine, that is reactive oxygen species scavenging activity, anticancer activity, viruses and bacteria inactivation etc. In this work, the water-soluble C60 fullerene derivative with l-hydroxyproline (C60(C5H9NO3)2, C60-Hyp) was studied. Extensive biomedical investigation of this compound, namely, antiradical activity in the reaction with stable diphenylpicrylhydrazyl radical, the binding to human serum albumin, photodynamic properties, cytotoxicity in glioblastoma A172 and lung carcinoma A549 cell lines, erythrocytes haemolysis, platelet aggregation, genotoxicity on human peripheral blood mononuclear cells was conducted. Moreover, the dynamic and structural characteristics of C60-Hyp-H2O binary system were obtained using molecular dynamic (MD) method, and size distribution along with ζ-potentials of C60-Hyp associates was measured.
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