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Updated: Dec 10, 2025

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
Published on: January 9, 2019
Diagnostic Considerations in the Evaluation of Large B-Cells on Lymph Node Cytology Specimens
Daniel F Boyer1, Sarah Choi1, Winston Lee1
1Department of Pathology, University of Michigan Hospital and Health System, Ann Arbor, Michigan, USA.
Abstract:
Fine needle aspiration (FNA) has become increasingly popular in the evaluation of lymph nodes for lymphoproliferative disorders, but there are limitations to accurate subclassification of lymphoma using morphology alone. This case aims to expand diagnostic considerations of large B-cell populations identified on FNA material. We also address the significance of Epstein-Barr virus (EBV) DNA in the workup of patients with suspected lymphoma by FNA.

