Related Experiment Video
Updated: Aug 3, 2026
10:15
The Use of the Ex Vivo Chandler Loop Apparatus to Assess the Biocompatibility of Modified Polymeric Blood Conduits
Published on: August 20, 2014
12.1K
CD47 as a Potential Target to Therapy for Infectious Diseases
Lamin B Cham1, Tom Adomati1, Fanghui Li1
1Institute of Immunology, Medical Faculty, University of Duisburg-Essen, Hufelandstr. 55, 45147 Essen, Germany.
Antibodies (Basel, Switzerland)
|September 5, 2020
Summary
Blocking CD47 (integrin-associated protein) with an antibody enhances immune cell function against viral infections. This approach boosts innate and adaptive immunity, offering potential for treating emerging infectious diseases.
Area of Science:
- Immunology
- Virology
- Infectious Diseases
Background:
- CD47 (integrin-associated protein) is expressed on healthy cells and upregulated by cancer and immune cells during infection.
- The CD47-SIRPα interaction inhibits macrophages and dendritic cells, while CD47-thrombospondin signaling inhibits T cells.
- CD47 blockade has shown immunosuppressive effects during various infections, including viral and bacterial pathogens.
Purpose of the Study:
- To investigate the impact of blocking CD47 on immune responses during viral infections.
- To evaluate the potential of anti-CD47 antibodies as a therapeutic strategy for infectious diseases.
Main Methods:
- Utilized an anti-CD47 antibody to block CD47 interactions.
- Assessed the activation and effector functions of macrophages, dendritic cells, and T cells in the context of viral infection.
Main Results:
- Blockade of CD47 significantly increased the activation and effector functions of macrophages, dendritic cells, and T cells.
- Enhanced innate and adaptive immunity resulted in a potent antiviral effect.
- The immune-stimulatory effects are broad, suggesting applicability to various nonresolving and emerging infections.
Conclusions:
- Blocking CD47 with an antibody enhances immune cell activity, promoting an antiviral state.
- Anti-CD47 antibody therapy holds promise for treating infectious diseases beyond its current clinical trials for cancer.
More Related Videos
Related Concept Videos
01:27Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
01:30Inhibitors of Viral Protein Synthesis
Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...