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Natural Flavonoids as Potential Angiotensin-Converting Enzyme 2 Inhibitors for Anti-SARS-CoV-2
Muchtaridi Muchtaridi1, M Fauzi1, Nur Kusaira Khairul Ikram2,3
1Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jl Raya 21.5, Bandung-Sumedang 45363, Indonesia.
Molecules (Basel, Switzerland)
|September 5, 2020
Summary
Natural flavonoids show promise in combating COVID-19 by inhibiting the ACE2 receptor, a key target for the virus. Further research into these compounds could lead to new therapeutic strategies against the pandemic.
Area of Science:
- Virology
- Pharmacology
- Biochemistry
Background:
- Coronaviruses (CoV), including SARS-CoV-2, cause severe global health issues.
- The COVID-19 pandemic highlights the urgent need for effective antiviral treatments.
- Angiotensin-converting enzyme 2 (ACE2) is a critical host cell receptor for SARS-CoV-2 entry.
Purpose of the Study:
- To explore the potential of natural flavonoids as inhibitors of the ACE2 receptor.
- To identify flavonoids with possible therapeutic efficacy against COVID-19.
Main Methods:
- Review of existing scientific literature on flavonoids, ACE2, and antiviral activities.
- Analysis of studies demonstrating the interaction between flavonoids and angiotensin-converting enzyme inhibition.
Main Results:
- Certain flavonoids exhibit angiotensin-converting enzyme inhibitory activity.
- Flavonoids have demonstrated antiviral properties in vitro.
- A plausible mechanism for flavonoid efficacy against COVID-19 involves ACE2 receptor interaction.
Conclusions:
- Natural flavonoids represent a potential therapeutic avenue for COVID-19 treatment.
- Targeting the ACE2 receptor with flavonoids could mitigate viral entry and infection.
- Further investigation into specific flavonoids is warranted for drug development.
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