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The effect of indomethacin on the psychomotor function of patients with rheumatic diseases
Abstract:
We have compared the effect of single and multiple doses of indomethacin and placebo on objective measurements of psychomotor impairment in patients. Following a single 50 mg dose (n = 8), indomethacin produced psychomotor disturbance in only those patients who had no recent history of NSAID exposure. After multiple doses of indomethacin (25 and 50 mg tid for 5 days), significant psychomotor impairment was observed. We conclude that other NSAIDs may induce cross-tolerance to the psychomotor effects of indomethacin. Tachyphylaxis may develop to the psychomotor disturbance caused by indomethacin.
Insights
Single doses of indomethacin caused psychomotor impairment only in new users. Multiple doses of nonsteroidal anti-inflammatory drugs (NSAIDs) led to significant impairment, suggesting cross-tolerance and potential tachyphylaxis.
Area of Science:
- Pharmacology
- Neuroscience
- Clinical Medicine
Background:
- Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for pain and inflammation.
- The psychomotor effects of NSAIDs, including indomethacin, are not fully understood.
- Patient history of NSAID use may influence drug response.
Purpose of the Study:
- To compare the effects of single and multiple doses of indomethacin on psychomotor function.
- To investigate the potential for cross-tolerance and tachyphylaxis to indomethacin's psychomotor effects.
Main Methods:
- Objective psychomotor impairment tests were administered to patients.
- Single 50 mg dose of indomethacin was given to 8 patients.
- Multiple doses (25 and 50 mg tid for 5 days) of indomethacin were administered.
Main Results:
- A single 50 mg dose of indomethacin caused psychomotor disturbance only in patients with no recent NSAID exposure.
- Multiple doses of indomethacin (25 and 50 mg tid) resulted in significant psychomotor impairment.
- Findings suggest that prior NSAID use may confer cross-tolerance to indomethacin's effects.
Conclusions:
- Cross-tolerance to indomethacin's psychomotor effects may occur with other NSAIDs.
- Tachyphylaxis, a rapid decrease in drug response, can develop with repeated indomethacin administration.
- Understanding these effects is crucial for patient safety and effective pain management.