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Entosis: From Cell Biology to Clinical Cancer Pathology
Izabela Mlynarczuk-Bialy1, Ireneusz Dziuba2, Agnieszka Sarnecka3
1Department of Histology and Embryology, Medical University of Warsaw, 02-004 Warszawa, Poland.
Cancers
|September 5, 2020
Summary
Entosis, where one cell invades another, may predict cancer prognosis. High entosis figures correlate with aggressive cancer and poor outcomes, potentially aiding tumor survival and treatment failure.
Area of Science:
- Cell Biology
- Cancer Research
- Histopathology
Background:
- Entosis is a cellular process where one cell actively invades another.
- Recent clinico-histopathological studies highlight entosis's role in cancer.
Purpose of the Study:
- To summarize the significance of entosis in cancer prognosis.
- To explore entosis as a potential independent prognostic predictor in cancer histopathology.
Main Methods:
- Review of published clinico-histopathological studies on entosis in various cancers.
- Analysis of entosis correlation with cancer prognosis in specific cancer types.
- In vitro cell culture models (BxPc3, MCF7) to study cell adhesion and entosis.
Main Results:
- Numerous entotic figures are associated with a more malignant cancer phenotype and poor prognosis.
- Entosis observed in head and neck squamous cell carcinoma, anal carcinoma, lung adenocarcinoma, pancreatic ductal carcinoma, and breast ductal carcinoma.
- Anticancer drugs can induce entosis, suggesting it as a survival mechanism for malignant cells.
Conclusions:
- Entosis may serve as a novel, independent prognostic factor in cancer.
- Entosis can facilitate malignant cell survival by providing refuge and potentially leading to therapeutic failure or recurrence.
- Cell adhesion conditions influence entosis in vitro, with implications for understanding this phenomenon.
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