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The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture
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In-Vivo Microsystems: A Review.

Paddy French1

  • 1Laboratory for Bioelectronics, Faculty of Electrical Engineering, Mathematics and Computer Science, TU Delft, Mekelweg 4, 2628CD Delft, The Netherlands.

Sensors (Basel, Switzerland)
|September 5, 2020
PubMed
Summary

This study reviews in-vivo sensors for medical monitoring. It covers surface devices, short-term implants like cardiac catheters, and long-term implants, discussing biocompatibility and safety challenges.

Area of Science:

  • Biomedical Engineering
  • Medical Device Technology
  • Sensor Technology

Background:

  • In-vivo sensors provide direct physiological measurements from living tissues.
  • Devices range from surface electrodes to implantable catheters and long-term implants.
  • Silicon-based sensors offer miniaturization and multi-sensor capabilities for devices like cardiac catheters.

Purpose of the Study:

  • To examine the applications of in-vivo devices.
  • To discuss challenges in biocompatibility and safety for implants.
  • To categorize in-vivo devices into surface, short/medium-term, and long-term implants.

Main Methods:

  • Review of existing literature and device types.
  • Analysis of applications in different medical contexts.
Keywords:
implantsin-vivo devicesmedical sensorsmicrosystems

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  • Discussion of regulatory and environmental considerations for implants.

    • Main Results:

    • Silicon sensors enable multi-sensor integration in small devices like cardiac catheters.
    • Short-term devices (e.g., catheters) are increasingly disposable, lowering costs.
    • Long-term implants face significant biocompatibility and safety hurdles.

    Conclusions:

    • In-vivo sensors are crucial for monitoring patient health across various applications.
    • Advancements in silicon technology facilitate smaller, more capable in-vivo devices.
    • Biocompatibility and safety are paramount for the successful development of implantable in-vivo sensors.