Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neutrophil-to-lymphocyte ratio is associated with cognitive performance in isolated REM sleep behavior disorder.

Sleep medicine·2026
Same author

Expanding the role of insulin resistance to the earliest phases of cognitive decline: Preliminary evidence.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Increased CSF levels of soluble AXL at diagnosis correlate with poor prognosis in patients affected by amyotrophic lateral sclerosis.

Brain communications·2026
Same author

Transcultural headache medicine: A framework for integrating cultural contexts into headache science and care - a call to action from the International Headache Society.

Cephalalgia : an international journal of headache·2026
Same author

Corneal Confocal Microscopy and Skin Biopsy to Differentiate Painful From Painless Diabetic Neuropathy: A Systematic Review With Multiple Meta-Analyses.

European journal of neurology·2026
Same author

WHO's essential medicines list: Additions for migraine and cluster headache.

Cephalalgia : an international journal of headache·2026
Same journal

Rimegepant for migraine prevention in clinical practice: A multicenter study including patients with prior anti-CGRP monoclonal antibody failure (GEMA project).

Cephalalgia : an international journal of headache·2026
Same journal

Cerebrovascular risk with calcitonin gene-related peptide monoclonal antibodies versus onabotulinumtoxinA in patients with migraine: A real-world pharmacoepidemiologic study in the National Institutes of Health All of Us Research Program.

Cephalalgia : an international journal of headache·2026
Same journal

Burning mouth syndrome and oral dysaesthetic/perceptual symptoms: Toward clinically actionable boundaries.

Cephalalgia : an international journal of headache·2026
Same journal

Effectiveness and clinical predictors of rimegepant for acute vertigo in vestibular migraine: A real-world cohort study.

Cephalalgia : an international journal of headache·2026
Same journal

Efficacy of digital therapeutic sinCephalea for personalised nutrition versus control for migraine prevention: A 12-week open-label randomised clinical trial.

Cephalalgia : an international journal of headache·2026
Same journal

SafeTy and effectiveness of Atogepant accoRding to the IHS outcome categories: A multicentric, prospective observational study in real life (the 24-week STAR study).

Cephalalgia : an international journal of headache·2026
See all related articles

Related Experiment Video

Updated: Dec 10, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.6K

Cluster headache not responsive to sumatriptan: A retrospective study.

Luca Giani1, Alberto Proietti Cecchini1, Alberto Astengo1

  • 1Neuroalgology Unit, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Italy.

Cephalalgia : an International Journal of Headache
|September 5, 2020
PubMed
Summary
This summary is machine-generated.

Cluster headache patients with longer, more frequent attacks are less likely to respond to subcutaneous sumatriptan. This suggests alternative pain mechanisms may be involved in non-responsive cases.

Keywords:
CGRPCluster headacheheadachehypothalamuspaintriptan

More Related Videos

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders
05:49

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders

Published on: November 1, 2024

1.1K
Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

9.3K

Related Experiment Videos

Last Updated: Dec 10, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

18.6K
Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders
05:49

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders

Published on: November 1, 2024

1.1K
Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
05:40

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache

Published on: July 29, 2021

9.3K

Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Subcutaneous sumatriptan is a primary acute treatment for cluster headache.
  • Approximately 25% of patients do not respond to this treatment, with reasons unclear.

Purpose of the Study:

  • To identify clinical characteristics differentiating cluster headache patients who respond to subcutaneous sumatriptan from those who do not.

Main Methods:

  • Retrospective analysis of clinical records from 277 cluster headache patients.
  • Defined responders as those with repeated satisfactory response within 15 minutes.

Main Results:

  • Of 206 patients using subcutaneous sumatriptan, 91% were responders.
  • Non-responders experienced significantly longer (median 100 vs. 60 minutes) and more frequent attacks (median 4 vs. 3 per day).

Conclusions:

  • Longer and more frequent cluster headache attacks may indicate pain mechanisms independent of 5HT1B/1D receptors.
  • These findings suggest potential alternative therapeutic targets for non-responders.