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Pharmacophore Modeling for Targets with Extensive Ligand Libraries: A Case Study on SARS-CoV-2 Mpro
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A protein interaction map identifies existing drugs targeting SARS-CoV-2

Claudia Cava1, Gloria Bertoli2, Isabella Castiglioni3

  • 1Institute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR), Via F. Cervi 93, 20090 Segrate-Milan, Milan, Italy. claudia.cava@ibfm.cnr.it.

BMC Pharmacology & Toxicology
|September 5, 2020
PubMed
Summary

This study used bioinformatics to identify potential COVID-19 treatments by analyzing gene expression and drug interactions. Several existing drugs show promise as antiviral therapies against SARS-CoV-2.

Keywords:
COVID-19DrugIn silico analysisMolecular dockingNetworkSARS-CoV-2

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