The Midwest ST-Elevation Myocardial Infarction Consortium: Design and Rationale
Mehmet Yildiz1, Scott Sharkey2, Frank V Aguirre3
1The Carl and Edyth Lindner Center for Research and Education at The Christ Hospital, Cincinnati, OH, United States of America.
Summary
A new Midwest STEMI Consortium registry captures comprehensive data on ST-elevation myocardial infarction (STEMI) patients, including high-risk groups like cardiac arrest (CA) and cardiogenic shock (CS). This enables crucial research to improve STEMI care and outcomes.
Area of Science:
- Cardiovascular Medicine
- Health Services Research
- Clinical Data Management
Background:
- Regional ST-elevation myocardial infarction (STEMI) care systems have improved outcomes, but national goals remain unmet.
- A lack of a comprehensive national STEMI registry hinders improvement, especially for high-risk subsets like cardiac arrest (CA) and cardiogenic shock (CS).
Purpose of the Study:
- To establish a comprehensive, multicenter, prospective STEMI registry without exclusionary criteria.
- To create a collaborative platform for clinical research to optimize STEMI care.
Main Methods:
- The Midwest STEMI Consortium (MSC) was formed by 4 regional STEMI care systems.
- A unified prospective database was created from individual center data, including risk factors, treatment times, and clinical outcomes up to 5 years.
- National Death Index was used for 10-year mortality assessment.
Main Results:
- The registry includes 14,911 consecutive STEMI patients (March 2003–January 2020).
- High-risk features identified: Age >75 years (19%), low ejection fraction <35% (15%), CA (10%), and CS (8%).
Conclusions:
- The MSC provides a unique platform for research into STEMI care, particularly for high-risk populations.
- This collaboration facilitates the optimization of STEMI treatment strategies and patient outcomes.
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