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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
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AKI in Hospitalized Patients with COVID-19

Lili Chan1,2,3,4, Kumardeep Chaudhary3,4,5, Aparna Saha3,4

  • 1Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.

Journal of the American Society of Nephrology : JASN
|September 5, 2020
PubMed

Insights

Acute kidney injury (AKI) is common in hospitalized COVID-19 patients, significantly increasing mortality risk. Kidney function recovery by discharge was poor, highlighting the severe impact of AKI on COVID-19 outcomes.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Early reports suggested a high incidence of acute kidney injury (AKI) in coronavirus disease 2019 (COVID-19) patients.
  • However, comprehensive data on AKI in hospitalized COVID-19 patients within the United States remained limited.

Purpose of the Study:

  • To describe the frequency of AKI among hospitalized COVID-19 patients.
  • To investigate AKI severity, dialysis requirements, kidney function recovery, and mortality associated with AKI in this population.

Main Methods:

  • A retrospective, observational study analyzed electronic health records of 3993 adult patients with laboratory-confirmed COVID-19 admitted between February 27 and May 30, 2020.
  • The study assessed AKI incidence, stage, dialysis needs, urine study findings, and in-hospital mortality, calculating adjusted odds ratios for mortality.

Main Results:

  • 46% of hospitalized COVID-19 patients developed AKI, with 19% requiring dialysis.
  • In-hospital mortality was substantially higher for patients with AKI (50%) compared to those without (8%).
  • Only 30% of AKI survivors recovered baseline kidney function by hospital discharge, with some recovery noted in post-hospital follow-up.

Conclusions:

  • Acute kidney injury is a frequent and severe complication of COVID-19 hospitalization.
  • AKI is strongly associated with increased mortality and impaired kidney function recovery.
  • Findings underscore the critical need for monitoring and managing kidney health in COVID-19 patients.
Abstract

Keywords:
COVID-19acute renal failureclinical nephrologydialysis

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