Cervical Cancer: Emerging Immune Landscape and Treatment
Luopei Guo1, Keqin Hua1,2
1Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, People's Republic of China.
Abstract:
Immune cells are essential for defending the body's balance and have increasingly been implicated in controlling tumor growth. In cervical cancer (CC), the immune landscape is extensively connected with human papillomavirus (HPV) status. Recent insights from studies have revealed that as a result of infection with HPV, immune cell populations such as lymphocytes or monocytes change during carcinogenesis. Immune therapy, in particular checkpoint inhibitors, those targeting PD-1 or PD-L1, has shown promising efficacy. This article reviews the immune landscape and immunotherapy of CC.
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