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Clearance of amyloid-beta with bispecific antibody constructs bound to erythrocytes
Ronald P Taylor1, Margaret A Lindorfer1, John P Atkinson2
1Department of Biochemistry and Molecular Genetics University of Virginia Charlottesville Virginia USA.
Alzheimer'S & Dementia (New York, N. Y.)
|September 5, 2020
Abstract:
We propose use of bispecific monoclonal antibody (mAb) complexes bound to erythrocytes to redress the lack of efficacy of anti-amyloid beta mAbs in Alzheimer's disease treatment. Our paradigm leverages erythrocyte complement receptor 1 to promote rapid and quantitative removal of amyloid beta from the circulation, and its subsequent removal from the brain as well.
Keywords:
Alzheimer's diseaseamyloid betabispecific monoclonal antibodiescomplement receptor 1erythrocytehuman
