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Related Concept Videos

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
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Alzheimer's Disease: Treatment01:22

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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Related Experiment Video

Updated: Dec 10, 2025

Author Spotlight: Advancing Alzheimer's Research &#8211; Exploring Early Detection and Multi-Omics Approaches
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Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

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Toward refining Alzheimer's disease into overlapping subgroups.

Erin R Hascup1, Kevin N Hascup1,2

  • 1Department of Neurology Center for Alzheimer's Disease and Related Disorders Neurosciences Institute Department of Pharmacology Springfield Illinois USA.

Alzheimer'S & Dementia (New York, N. Y.)
|September 5, 2020
PubMed
Summary
This summary is machine-generated.

Alzheimer's disease (AD) may stem from multiple causes, not a single factor. Understanding these complex, interrelated factors could lead to better Alzheimer's disease treatments and biomarker discovery.

Keywords:
cellular senescencehyperexcitable neuronal networksmetabolic syndromemitochondrial cascade hypothesissleep disturbancestraumatic brain injurytwo‐hit vascular hypothesis

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Area of Science:

  • Neurodegenerative Disorders
  • Gerontology
  • Neuropathology

Background:

  • Alzheimer's disease (AD) is a progressive neurodegenerative disorder with limited treatment efficacy.
  • Current therapeutic strategies targeting amyloid plaques or neurofibrillary tangles have not altered disease progression.
  • AD poses a significant public health challenge due to its increasing prevalence.

Purpose of the Study:

  • To propose an alternative hypothesis for Alzheimer's disease etiology, viewing it as a multifactorial disorder.
  • To initiate a discussion on the multiple, interrelated causalities of AD.
  • To explore how subgroup identification can improve biomarker discovery and pharmacotherapeutic strategies for AD.

Main Methods:

  • Conceptual review and hypothesis generation.
  • Analysis of existing literature on AD pathogenesis.
  • Proposal of a multifactorial model for AD.

Main Results:

  • The study posits that AD results from multiple, interconnected causal factors rather than a single initiating event.
  • Identifying patient subgroups based on these causalities may enhance biomarker identification.
  • This approach could lead to more targeted and effective pharmacotherapeutic interventions for specific AD patient populations.

Conclusions:

  • A multifactorial hypothesis offers a new perspective on Alzheimer's disease pathogenesis.
  • Subgrouping patients based on interrelated causalities is crucial for advancing AD research and treatment.
  • Addressing the complexity of AD through a multifaceted approach is essential for future therapeutic success.