Related Experiment Video

Updated: Dec 10, 2025

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
08:09

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Published on: March 24, 2017

8.4K

Serum response factor-cofactor interactions and their implications in disease

John Oloche Onuh1, Hongyu Qiu1

  • 1Center for Molecular and Translational Medicine, Institute of Biomedical Science, Georgia State University, Atlanta, GA, USA.

The FEBS Journal
|September 5, 2020
PubMed

Insights

Serum response factor (SRF) is vital for cell function and disease. This review details how SRF interacts with cofactors, offering insights into cardiovascular diseases and cancer for potential treatments.

Area of Science:

  • Molecular biology
  • Genetics
  • Biochemistry

Background:

  • Serum response factor (SRF) is a key transcription factor involved in cellular processes and disease development.
  • SRF regulates gene expression by binding to CArG DNA elements, often with the help of cofactors.
  • The precise mechanisms of SRF activation and its role in various conditions require further elucidation.

Purpose of the Study:

  • To review recent advancements in understanding the molecular mechanisms of SRF activation.
  • To explore the impact of SRF in both physiological functions and pathological conditions.
  • To highlight the interaction of SRF with its major cofactor families: myocardin and ternary complex factors.

Main Methods:

  • Literature review of recent studies on SRF molecular mechanisms.
  • Analysis of SRF interactions with myocardin family and ternary complex factor cofactors.
  • Synthesis of information on SRF's role in physiological and pathological contexts.

Main Results:

  • SRF's critical role in gene regulation is mediated through interactions with diverse cofactors.
  • Two main classes of SRF cofactors, myocardin family members and ternary complex factors, have been identified.
  • Understanding these interactions provides insights into disease pathogenesis, particularly in cardiovascular diseases and cancer.

Conclusions:

  • Elucidating SRF cofactor interactions is crucial for understanding gene regulation and disease.
  • This knowledge opens avenues for developing targeted pharmacological interventions for diseases like cancer and cardiovascular disorders.
  • Further research into SRF mechanisms can lead to novel therapeutic strategies.
Keywords:
bindingcofactorsmechanismsmyocardinserum response factortranscription

More Related Videos

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF311:44

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3

Published on: January 24, 2016

12.3K
Applying Fluorescence Resonance Energy Transfer FRET to Examine Effector Translocation Efficiency by Coxiella burnetii during siRNA Silencing10:29

Applying Fluorescence Resonance Energy Transfer FRET to Examine Effector Translocation Efficiency by Coxiella burnetii during siRNA Silencing

Published on: July 6, 2016

11.0K

Related Concept Videos

Cofactors and Coenzymes01:24

Cofactors and Coenzymes

Enzymes are proteins made of amino acids. The functional group of each constituent amino acid catalyzes a wide variety of chemical reactions via ionic interactions or acid-base reactions. However, amino acids cannot catalyze oxidation-reduction and group transfer reactions and need to be aided by non-protein components called cofactors. Cofactors are also referred to as the chemical teeth of an enzyme.
Cofactors can be metallic ions or organic molecules called coenzymes. These types of helper...
12.4K
Cofactors and Coenzymes01:27

Cofactors and Coenzymes

Enzymes require additional components for proper function. There are two such classes of molecules: cofactors and coenzymes. Cofactors are metallic ions and coenzymes are non-protein organic molecules. Both of these types of helper molecule can be tightly bound to the enzyme or bound only when the substrate binds.
86.2K
Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.7K
General Transcription Factors01:30

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
6.4K
Transcriptional Regulation: Riboswitches01:23

Transcriptional Regulation: Riboswitches

Riboswitches are RNA elements that regulate gene expression by altering their secondary structures in response to specific effector molecules. These elements, located in the leader regions of certain mRNAs, act as transcriptional regulators by toggling between alternative conformations to control downstream gene expression. Riboswitch-mediated regulation is a precise mechanism for modulating biosynthetic pathways, as exemplified by the riboflavin biosynthesis pathway in Bacillus...
386
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
8.4K