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Updated: Jun 19, 2026

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Published on: August 19, 2021

Binary grading may be more appropriate for endometrial cancer

Kazibe Koyuncu¹, Duygu Altın¹, Batuhan Turgay¹

¹Department of Obstetrics and Gynecology, Ankara University Faculty of Medicine, Ankara, Turkey.

Journal of the Turkish German Gynecological Association

|September 5, 2020

Summary

Advanced stage, high-grade tumors, and positive peritoneal cytology are key prognostic factors for endometrial cancer survival. A simpler two-grade system may suffice, as low-grade tumors share similar outcomes.

Keywords:

Endometrial cancer grade peritoneal cytology prognostic factor survival

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Area of Science:

Gynecologic Oncology
Cancer Prognostics

Background:

Endometrial cancer prognosis is influenced by various factors.
Accurate identification of these factors is crucial for patient management.

Purpose of the Study:

To determine the survival impact of prognostic factors in endometrial cancer.
To identify independent risk factors for overall survival (OS), progression-free survival (PFS), and disease-specific survival (DSS).

Main Methods:

Retrospective analysis of 276 endometrial cancer patients undergoing staging surgery.
Pathology reassessment by a gynecopathologist.
Kaplan-Meier and Cox proportional hazard analyses were used.

Main Results:

Stage and Grade 3 (G3) histology were independent risk factors for OS and PFS.
Positive peritoneal cytology independently predicted OS but not PFS.
Stage was the sole independent predictor for DSS.
G1 and G2 histology showed similar, favorable prognoses compared to G3.

Conclusions:

Advanced stage, high-grade histology (G3), and positive peritoneal cytology are significant independent prognostic factors for endometrial cancer.
A binary histological grading system (e.g., G3 vs. non-G3) may be a simpler alternative to the current three-grade system.