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Depositing annotated sequences in GenBank: there needs to be a better way
1Department of Biology, University of Western Ontario, 1151 Richmond Street, London N6A 5B7, Canada.
Briefings in Functional Genomics
|September 5, 2020
Summary
Submitting genetic sequences to the National Center for Biotechnology Information (NCBI) requires better tools. Current infrastructure for uploading annotated eukaryotic genomes is inefficient, prompting researchers to skip annotations.
Area of Science:
- Genomics
- Bioinformatics
- Molecular Biology
Background:
- Submitting genetic sequences to the National Center for Biotechnology Information (NCBI) is crucial for life sciences research and publication.
- Advancements in sequencing technologies increase the importance of data submission and annotation.
Purpose of the Study:
- To highlight the inefficiencies and usability issues with the current NCBI data submission infrastructure, particularly for eukaryotic genome annotations.
- To advocate for the development of improved software for depositing annotated sequences in GenBank.
Main Methods:
- Critical analysis of existing NCBI data submission infrastructure and resources.
- Review of the impact of current limitations on researcher practices regarding genome annotation.
Main Results:
- The current NCBI infrastructure for uploading sequence data, especially eukaryotic genome annotations, is inefficient and difficult to use.
- These shortcomings lead some researchers to omit annotations from their submissions, compromising data quality.
Conclusions:
- The existing tools for depositing annotated sequences in GenBank are inadequate.
- There is an urgent need for sophisticated, user-friendly software to streamline the submission of annotated eukaryotic genomes to NCBI.
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