Sensitivity and specificity of choroidal thickness measurement by EDI-OCT for central serous chorioretinopathy
Javier Orduña-Azcona1,2, Elia Pérez-Fernández3, Ana M Guadilla4
1Ophthalmology Unit, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, Spain. dr.orduna@outlook.com.
Purpose:
To evaluate the utility of choroidal thickness (CT) measurement by enhanced depth imaging optical coherence tomography (EDI-OCT) for central serous chorioretinopathy (CSC) diagnosis.
Methods:
Cross-sectional comparative study of 62 consecutive patients: 38 with acute CSC and 24 with macular subretinal fluid from differential diagnoses (DD). Subfoveolar choroidal thickness was measured using EDI 9-mm horizontal protocol. We evaluated sensitivity, specificity and intraclass correlation coefficient.
Results:
Mean subfoveolar CT was greater in CSC group than in DD group (465.45 ± 115.42 μm vs. 347.54 ± 111.27 μm, p < 0.001). The best threshold measure was 390 μm in patients younger than 50 years giving a sensitivity of 89.7% (CI 95%: 73.6-100%) and a specificity of 75% (CI 95%: 40.9-87.3%). For patients older than 50 years best threshold measure was found at 400 μm giving a sensitivity of 45.5% (CI 95%: 21.3-72%) and a specificity of 80% (CI 95%: 58.4-91.9%). Intraclass correlation coefficient for CT measurement was 0.87 (CI 95%: 0.74-0.93).
Conclusion:
CT measurement with EDI-OCT helps to differentiate CSC from other causes of macular subretinal fluid in patients younger than 50 years.
