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Intravenous Admixture Preparation Considerations, Part 6: pH Considerations -- Applications.
1International Journal of Pharmaceutical Compounding. lallen@ijpc.com.
International Journal of Pharmaceutical Compounding
|September 4, 2020
Summary
Maintaining the correct pH is crucial for parenteral dosage forms. Compounding intravenous admixtures requires careful consideration of pH due to varying additive and vehicle values.
Area of Science:
- Pharmaceutical Sciences
- Drug Formulation
- Intravenous Therapy
Background:
- pH is a critical factor in parenteral dosage form formulation.
- Compounding intravenous admixtures presents pH challenges due to diverse additives and vehicles.
- Many parenteral medications require complex compounding steps, increasing pH considerations.
Purpose of the Study:
- To highlight the importance of pH in parenteral admixture compounding.
- To underscore the complexities introduced by varying pH values of components.
- To emphasize the need for careful pH assessment in intravenous admixture preparation.
Main Methods:
- Review of common parenteral admixture compounding practices.
- Analysis of pH considerations in drug dissolution and dilution.
- Examination of pH challenges in parenteral nutrition formulations.
Main Results:
- pH variability is a significant complication in parenteral admixture compounding.
- Dissolution of lyophilized powders and drug dilutions require pH management.
- Parenteral nutrition admixtures involve multiple components with potentially different pH values.
Conclusions:
- Careful pH evaluation is essential for safe and effective parenteral admixture compounding.
- Understanding component pH interactions is vital for successful formulation.
- Each intravenous admixture presents unique pH-related challenges that must be addressed.
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