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Dietary Oxalate Intake and Kidney Outcomes
Matteo Bargagli1,2, Maria Clarissa Tio3, Sushrut S Waikar4
1U.O.C. Nefrologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, Italy.
Nutrients
|September 5, 2020
Summary
Dietary oxalate, a plant molecule with no human function, is eliminated by kidneys. High oxalate intake can harm kidneys, causing stones and disease.
Area of Science:
- Nephrology
- Toxicology
- Human Physiology
Background:
- Oxalate is a plant-derived molecule and a toxic metabolite.
- It has no known physiological function in humans.
- Kidneys eliminate oxalate via glomerular filtration and tubular secretion.
Purpose of the Study:
- To review the current literature on the association between dietary oxalate intake and kidney outcomes.
- To understand the impact of dietary oxalate on kidney health.
Main Methods:
- Literature review of studies investigating dietary oxalate and kidney health.
- Analysis of research on kidney-related conditions linked to oxalate.
Main Results:
- Increased dietary oxalate load is associated with kidney conditions.
- Conditions include calcium oxalate nephrolithiasis and acute/chronic kidney disease.
Conclusions:
- Dietary oxalate intake is a significant factor in kidney health.
- Further research is warranted to fully elucidate the oxalate-kidney relationship.
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