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An Update on Antimicrobial Peptides (AMPs) and Their Delivery Strategies for Wound Infections

Viorica Patrulea1,2, Gerrit Borchard1,2, Olivier Jordan1,2

  • 1Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, 1 Rue Michel Servet, 1211 Geneva, Switzerland.

Pharmaceutics
|September 5, 2020
PubMed

Insights

Antimicrobial peptides (AMPs) show promise for treating wound infections, especially those resistant to antibiotics. This review explores AMPs, AMP dendrimers (AMPDs), and novel delivery systems for enhanced wound healing.

Area of Science:

  • Biomedical Science
  • Wound Healing Research
  • Antimicrobial Therapy

Background:

  • Bacterial wound infections impede healing, often resisting conventional topical antimicrobials due to poor drug penetration, resistance, and side effects.
  • Multidrug-resistant and biofilm-forming pathogens pose significant challenges in wound infection management.
  • There is a critical need for effective antimicrobial strategies to overcome these limitations and promote wound healing.

Purpose of the Study:

  • To review the potential of antimicrobial peptides (AMPs) in combating wound infections, particularly those caused by multidrug-resistant and biofilm-forming bacteria and fungi.
  • To discuss antimicrobial peptide dendrimers (AMPDs) as potent antimicrobial agents.
  • To explore various AMP delivery strategies and emerging technologies for skin therapy.

Main Methods:

  • Literature review focusing on antimicrobial peptides, AMP dendrimers, and their applications in wound infection treatment.
  • Analysis of current preclinical and clinical studies involving AMPs.
  • Examination of diverse AMP delivery systems, including polymers, scaffolds, films, wound dressings, and nanoparticles.
  • Consideration of advanced technologies like CRISPR-Cas for AMP delivery.

Main Results:

  • Antimicrobial peptides (AMPs) demonstrate high efficacy against multidrug-resistant and biofilm-forming pathogens relevant to wound infections.
  • Antimicrobial peptide dendrimers (AMPDs) are identified as potent antimicrobial agents with significant therapeutic potential.
  • Various delivery strategies, including nanoparticles and advanced wound dressings, enhance AMP efficacy and modulate healing rates.
  • Emerging technologies like CRISPR-Cas offer novel avenues for targeted AMP delivery in skin therapy.

Conclusions:

  • Antimicrobial peptides (AMPs) represent a promising therapeutic class for managing complex wound infections.
  • Innovative delivery systems and technologies are crucial for optimizing AMP efficacy and overcoming challenges in wound healing.
  • Further research and clinical translation of AMP-based therapies and delivery strategies are warranted for improved patient outcomes.
Keywords:
AMP carriers and delivery systemsAMP conjugatesantimicrobial peptides (AMPs)antimicrobial resistancebacterial infectionmultidrug resistancenon-healing wounds

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