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How to interpret lactate.

Dilshad Marikar1, Pratusha Babu1, Miriam Fine-Goulden2

  • 1Paediatric Department, Addenbrooke's Hospital, Cambridge, UK.

Archives of Disease in Childhood. Education and Practice Edition
|September 5, 2020
PubMed
Summary
This summary is machine-generated.

High blood lactate levels indicate poor outcomes in sick children. This paper reviews evidence on using lactate testing as a diagnostic and prognostic tool for acutely unwell children, improving clinical understanding.

Keywords:
biochemistryneonatologyphysiologyresuscitation

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Area of Science:

  • Pediatric Critical Care Medicine
  • Biochemistry
  • Clinical Diagnostics

Background:

  • Hyperlactataemia is linked to adverse outcomes in acutely unwell patients.
  • Blood lactate testing is a standard investigation for sepsis management.
  • Clinical interpretation of lactate levels in acute illness requires further understanding.

Purpose of the Study:

  • To review the evidence for lactate's role in diagnosing acutely unwell children.
  • To evaluate lactate as a prognostic marker in pediatric acute illness.
  • To enhance clinical understanding of lactate's significance in pediatric critical care.

Main Methods:

  • Systematic review of existing literature.
  • Analysis of diagnostic accuracy studies.
  • Evaluation of prognostic studies in pediatric populations.

Main Results:

  • Lactate is a valuable diagnostic marker in acutely unwell children.
  • Elevated lactate levels correlate with increased mortality and morbidity.
  • Evidence supports lactate's utility in risk stratification and treatment guidance.

Conclusions:

  • Lactate measurement is crucial for managing acutely unwell children.
  • Improved understanding of lactate interpretation can guide clinical decision-making.
  • Lactate serves as both a diagnostic and prognostic indicator in pediatric acute care.