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Pembrolizumab-Induced Cold Agglutinin Disease
Osman Atiq1, Saad O Atiq2, Zainab O Atiq3
1Department of Internal Medicine, Unity Health, Searcy, AR, USA.
The American Journal of Case Reports
|September 5, 2020
Summary
Pembrolizumab therapy for metastatic lung cancer can cause cold agglutinin disease (CAD), a rare autoimmune hemolytic anemia. Early diagnosis and treatment with Rituximab are crucial for recovery, as demonstrated in this case report.
Area of Science:
- Oncology
- Immunology
- Hematology
Background:
- Immunotherapy, particularly with Pembrolizumab, is transforming metastatic lung cancer treatment.
- While generally well-tolerated, immunotherapy can cause adverse events, including autoimmune hemolytic anemia.
- Cold agglutinin disease (CAD) is a rare form of autoimmune hemolytic anemia.
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