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Updated: Dec 9, 2025

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
Impact of changes to national UK Guidance on testing for gestational diabetes screening during a pandemic: a
Y van-de-l'Isle1, P J Steer2, I Watt Coote1
1Department of Obstetrics, Maternal Medicine Service, St George's Hospital, London, UK.
Insights
The Royal College of Obstetricians and Gynaecologists (RCOG) Covid-19 screening for gestational diabetes (GDM) significantly reduced detection rates. This RCOG protocol missed over half of GDM cases, failing to meet National Institute for Health and Clinical Excellence (NICE) standards.
Area of Science:
- Obstetrics and Gynecology
- Endocrinology
- Public Health
Background:
- Gestational diabetes (GDM) poses risks to both mother and fetus.
- Standardized screening protocols are crucial for timely diagnosis and management.
- The COVID-19 pandemic necessitated adaptations in healthcare, including GDM screening.
Purpose of the Study:
- To compare the detection rates of GDM using the National Institute for Health and Clinical Excellence (NICE) guidelines versus the Royal College of Obstetricians and Gynaecologists (RCOG) COVID-19 pandemic recommendations.
- To evaluate the effectiveness of the RCOG's adapted GDM screening protocol during the pandemic.
Main Methods:
- A retrospective cohort study analyzed prospectively collected data from women delivering between January 2016 and May 2020.
- Data from a London Teaching Hospital was used.
- Detection rates were compared between NICE and RCOG criteria, with follow-up testing for women screening negative under RCOG guidelines.
Main Results:
- The RCOG guidance resulted in a significant decrease in GDM detection rates, from 7.7% to 4.2% (P=0.0003).
- Of 230 women who initially tested negative under RCOG criteria but underwent further testing, 47 (20.4%) were diagnosed with GDM per NICE criteria.
- The RCOG COVID-19 screening regime failed to detect 57% of women who were subsequently identified as having GDM.
Conclusions:
- The RCOG COVID-19 gestational diabetes screening protocol demonstrated a significantly lower detection rate compared to NICE guidelines.
- The adapted RCOG screening approach during the pandemic was insufficient and cannot be recommended for general use due to its failure to identify a substantial proportion of GDM cases.
- This highlights the importance of maintaining robust GDM screening protocols even during public health crises.
Objective:
To examine the differences in detection rate for gestational diabetes (GDM) comparing the methodology recommended by the National Institute for Health and Clinical Excellence (NICE) compared with testing described as appropriate during the Covid-19 pandemic by the Royal College of Obstetricians and Gynaecologists (RCOG).
Design:
Cohort study of women delivering between 1 January 2016 and 1 July 2020.
Setting:
London Teaching Hospital.
Population:
All women delivering between 1 January 2016 and 13 May 2020 and follow up of women screening negative between 1 April 2020 and 13 May 2020.
Methods:
Retrospective study of prospectively collected data.
Main Outcome Measures:
Detection rate of gestational diabetes.
Results:
Using the RCOG guidance, the overall rate of women identified as having gestational diabetes fell from 7.7% (1853/24168) to 4.2% (35/831)(P = 0.0003). Of 230 women who tested negative according to the RCOG criteria from 1 April to 13 May but who subsequently had an oral glucose tolerance test, 47 (20.4%) were diagnosed as having gestational diabetes according to the NICE criteria.
Conclusions:
In our setting, the RCOG Covid-19 gestational diabetes screening regime failed to detect 47 of 82 (57%) women subsequently identified as gestational diabetics, and therefore cannot be recommended for general use.
Tweetable Abstract:
Screening for GDM using RCOG Covid criteria reduced detection rates.
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