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Updated: Dec 9, 2025

Monitoring GPCR-β-arrestin1/2 Interactions in Real Time Living Systems to Accelerate Drug Discovery
Published on: June 28, 2019
SnapShot: β-Arrestin Functions
Seungkirl Ahn1, Sudha K Shenoy2, Louis M Luttrell3
1Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Abstract:
The arrestins are ubiquitously expressed adaptor proteins that orchestrate transmembrane signaling cascades triggered by the 7-transmembrane G protein-coupled receptors. While originally discovered as proteins that block receptor-G protein coupling, arrestins are now appreciated for their expanding repertoire of dynamic protein interactions and cellular functions.
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