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Updated: Dec 9, 2025

Author Spotlight: Discovering New Alkaloids in Plants with Advanced Mass Spectrometry Techniques
Published on: March 8, 2024
Tropane alkaloids from the stem bark of Erythroxylum bezerrae
Luana San de O Brito1, Francisco das Chagas L Pinto1, Manoel Odorico M de Filho2
1Departamento de Química Orgânica e Inorgânica, Centro de Ciências, Universidade Federal do Ceará, 60440-900, Fortaleza, CE, Brazil.
Abstract:
Six previously undescribed tropane alkaloids, designated as erythrobezerrines A-F, were isolated from the EtOH extract from the stem bark of Erythroxylum bezerrae Plowman. Their structures were elucidated based on the interpretation of the NMR and MS data and in some instances, confirmed by X-ray diffraction analysis. The cytotoxicity of the isolated compounds was evaluated against the cancer cell lines L929, PC-3, HCT-116, SNB-19 and NCI-H460, but only erythrobezerrine C showed moderate activity with IC50 values of 3.38 and 5.43 μM for HCT-116 and NCI-H460, respectively.
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