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Steroidal saponins from Raphia vinifera and their cytotoxic activity
Godloves Fru Chi1, Rodrigue V T Sop1, Armelle T Mbaveng2
1Department of Organic Chemistry, Faculty of Science University of Yaoundé 1, P.O. Box 812 Yaoundé, Cameroon; Department of Chemistry, University of Botswana, Private Bag 0022, Gaborone, Botswana.
Abstract:
Phytochemical analysis of the fruits of Raphia vinifera led to the isolation of four new steroidal saponins (1-4), along with six known secondary metabolites (6-10). The structures of the isolated compounds were determined based on the analyses of NMR and mass spectrometric data, and chemical degradation reactions. Among the compounds tested, 1 and 4 showed the most promising cytotoxic activity against the drug-sensitive CCRF-CEM leukemia cell lines, with IC50 values of 3.55 µM and 7.14 µM, respectively.
