Bidirectional relationship between diabetes and pulmonary function: a systematic review and meta-analysis.
Rui-Heng Zhang1, Yao-Hua Cai1, Lin-Ping Shu1
1Beijing Tongren Hospital, Capital Medical University, Beijing, China.
This study reveals a two-way link between diabetes and lung function, where poorer lung capacity increases diabetes risk and diabetes negatively impacts pulmonary function, particularly with complications.
Area of Science:
- Pulmonary Medicine
- Endocrinology
- Systematic Reviews
Background:
- Growing evidence suggests the lungs are affected by diabetes pathophysiology.
- Reduced pulmonary function is linked to an increased risk of developing diabetes.
Purpose of the Study:
- To systematically review and conduct a meta-analysis on the bidirectional relationship between diabetes and pulmonary function.
Main Methods:
- Searched MEDLINE, Embase, Cochrane Library, and Web of Science for relevant studies.
- Included 93 studies in the meta-analysis, with independent data extraction and bias assessment by two reviewers.
Main Results:
- Diabetes was associated with reduced forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC).
- Diabetes increased the risk of restrictive spirometry pattern (RSP).
- Decreased FVC predicted a higher risk of incident diabetes.
Conclusions:
- A bidirectional relationship exists between diabetes and pulmonary function.
- Further research is needed to understand the temporal dynamics and mediating factors in this relationship.
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