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Markers of coagulation dysfunction and inflammation in diabetic and non-diabetic COVID-19

Seshadri Reddy Varikasuvu1, Saurabh Varshney2, Naveen Dutt3

  • 1Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Deoghar, Jharkhand, 814152, India. lifeschemistry@live.com.

Journal of Thrombosis and Thrombolysis
|September 5, 2020
PubMed

Insights

Diabetic patients with COVID-19 showed significantly higher levels of inflammatory markers and coagulation dysfunction compared to non-diabetic patients. This suggests increased susceptibility to severe complications in diabetic individuals.

Area of Science:

  • Medical research
  • Infectious diseases
  • Endocrinology

Background:

  • COVID-19 presents diverse clinical manifestations, with a notable impact on coagulation and inflammation.
  • Diabetes mellitus is a known risk factor for severe infections and adverse outcomes.
  • Understanding the interplay between diabetes, COVID-19, and hypercoagulability is crucial for patient management.

Discussion:

  • Diabetic COVID-19 patients exhibited elevated serum ferritin, C-reactive protein, interleukin-6, fibrinogen, and D-dimers.
  • These findings indicate a heightened inflammatory response and pro-thrombotic state in diabetic individuals with COVID-19.
  • The observed differences were statistically significant, suggesting a genuine biological effect.

Key Insights:

  • Diabetic COVID-19 patients experience more severe inflammation and coagulation dysfunction.
  • Markers such as serum ferritin, CRP, IL-6, fibrinogen, and D-dimers are significantly elevated.
  • This heightened inflammatory and hypercoagulable state may predispose diabetic patients to worse COVID-19 outcomes.

Outlook:

  • Further research is warranted to explore the specific mechanisms driving these differences.
  • Investigating targeted therapeutic strategies for diabetic COVID-19 patients is essential.
  • Long-term follow-up studies can elucidate the chronic implications of these findings.

Keywords:
COVID-19D-dimerDiabetesInflammation

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