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Craniofacial Dysmorphology in Unilateral Coronal Synostosis Using Three-Dimensional Landmark-Based Analysis With
John W Rutland1,2, Bradley N Delman3, Christopher Bellaire2
1Department of Neurosurgery.
The Journal of Craniofacial Surgery
|September 5, 2020
Summary
Geometric morphometrics quantify skull changes in unilateral coronal synostosis (UCS). UCS patients show significant angular deviations and altered skull dimensions compared to controls.
Area of Science:
- Craniofacial surgery
- Medical imaging
- Computational anatomy
Background:
- Geometric morphometrics with Procrustes superimposition quantifies 3D structural changes.
- Unilateral coronal synostosis (UCS) involves complex craniofacial dysmorphology.
- This study integrates CT imaging and geometric morphometrics to analyze UCS.
Purpose of the Study:
- To quantify craniofacial dysmorphology in unilateral coronal synostosis (UCS) using geometric morphometrics.
- To identify specific patterns of skull deformation in UCS patients.
- To assess the utility of geometric morphometrics in characterizing UCS.
Main Methods:
- High-resolution CT imaging of 41 UCS patients and 41 controls.
- Identification of 31 anatomical landmarks for Procrustes superimposition.
- Analysis of angular deviations, lengths, and principal components (PCA) of craniofacial shape.
Main Results:
- UCS patients exhibited significant angular deviations in the skull base, posterior fossa, and vertex.
- Increased transverse (left-right) lengthening and decreased midline AP shortening were observed in UCS patients.
- PCA indicated skull flattening and right-sided deformity with mediolateral expansion as key variations.
Conclusions:
- Geometric morphometrics effectively quantified significant craniofacial dysmorphology in UCS.
- This approach aids in characterizing dynamic changes associated with unilateral coronal synostosis.
- The findings may inform clinical understanding and treatment of UCS.
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