No Observed Effect Level (NOEL) for Systemic Inflammation by Copper and Zinc in Welding Fumes

: Copper and zinc containing welding fumes are able to induce systemic inflammation in healthy subjects. In this study the no observed effect levels (NOEL) for welding fumes containing either copper or zinc were assessed.Fifteen healthy male volunteers participated in an exposure. Each subject was exposed to two different concentrations of both, copper and zinc containing welding fumes. Exposure was performed in the Aachen Workplace Simulation Lab.The NOEL was found at metal concentrations between 0.2 and 0.3 mg/m for copper and between 0.8 and 1.2 mg/m for zinc.The NOEL identified in this study was about a factor of 10 higher than the German workplace threshold limit values (TLV). However, TLV in other countries was in the same range or even higher than the NOEL indicating a considerable risk for workers.