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Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound
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New progress on the study of aortic stiffness in age-related hypertension

John O Onuh1, Hongyu Qiu

  • 1Center for Molecular and Translational Medicine, Georgia State University, Atlanta, Georgia, USA.

Journal of Hypertension
|September 5, 2020
PubMed

Insights

Aortic stiffening is increasingly recognized as a cause of hypertension in older adults. Understanding its causes, including aging and inflammation, is crucial for preventing cardiovascular disease.

Area of Science:

  • Gerontology
  • Cardiovascular Medicine
  • Pathophysiology

Background:

  • Hypertension is a leading cause of death and illness in the elderly.
  • Aortic stiffening is a newly identified contributor to age-related hypertension.
  • Understanding aortic stiffness is key to managing hypertension in older populations.

Purpose of the Study:

  • To review recent advancements in understanding the causes of aortic stiffening.
  • To explore the link between aortic stiffening and the development of hypertension.
  • To examine the roles of aging, inflammation, metabolic syndrome, and neuroendocrine factors.

Main Methods:

  • Literature review of recent research on aortic stiffening and hypertension.
  • Analysis of the interplay between aging, inflammation, metabolic factors, and neuroendocrine influences.
  • Synthesis of current knowledge on the pathogenesis of age-related hypertension.

Main Results:

  • Aortic stiffening is a significant factor in the development of hypertension in older individuals.
  • Aging, inflammation, metabolic syndrome, and neuroendocrine factors contribute to aortic stiffening.
  • Interactions among these factors exacerbate the pathogenesis of hypertension.

Conclusions:

  • Aortic stiffening is a critical target for preventing and controlling hypertension in the elderly.
  • Further research into the multifaceted causes of aortic stiffening is warranted.
  • Targeting aortic stiffening may offer novel therapeutic strategies for cardiovascular disease prevention.

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