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Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

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MRI phase offset correction method impacts quantitative susceptibility mapping.

Shaeez Usman Abdulla¹, David Reutens¹, Steffen Bollmann¹

¹Centre for Advanced Imaging, University of Queensland, Brisbane, Australia.

Magnetic Resonance Imaging

|September 5, 2020

Summary

This summary is machine-generated.

Phase offset correction is crucial for quantitative susceptibility mapping (QSM) in 7T MRI. Single echo time methods generally yield more accurate and less noisy QSM than multi-echo time methods.

Keywords:

Frequency shift mapping Magnetic resonance imaging Offset correction Parallel imaging Phantom Phase imaging Quantitative susceptibility mapping Ultra-high field

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Area of Science:

Magnetic Resonance Imaging (MRI)
Biomedical Engineering
Medical Physics

Background:

Ultra-high field (7T) MRI requires phase offset correction for accurate quantitative susceptibility mapping (QSM) of tissues.
Existing phase offset correction methods for gradient recalled echo (GRE) MRI vary in their use of single or multiple echo time data.
The impact of these correction methods on derived quantitative susceptibility values remains incompletely understood.

Purpose of the Study:

To evaluate the effect of different phase offset correction methods on quantitative susceptibility values derived from 7T MRI phase images.
To compare the performance of single and multiple echo time correction techniques.
To assess the accuracy and noise levels of QSM generated by various correction methods.

Main Methods:

Utilized 32-channel multi-echo time 7T GRE and ultra-short echo time PETRA MRI data from a susceptibility phantom and three human brains.
Applied four established phase offset correction methods: two single echo time and two multiple echo time approaches.
Analyzed combined phase images and assessed quantitative susceptibility values obtained for the phantom and human brains.

Main Results:

Correction method effectiveness decreased with increased echo time, decreased signal intensity, and reduced coil sensitivity profile overlap.
Quantitative susceptibility values and their echo time dependency were found to be method-specific.
Single echo time phase offset correction methods demonstrated a tendency towards more accurate and less noisy QSM compared to multiple echo time methods.

Conclusions:

The choice of phase offset correction method significantly influences quantitative susceptibility mapping results at 7T.
Single echo time correction approaches appear more robust for generating accurate and less noisy QSM.
Further investigation into method-specific performance is warranted for optimizing QSM protocols at ultra-high fields.