Carbon Monoxide Controllable Targeted Gas Therapy for Synergistic Anti-inflammation

Carbon monoxide (CO) plays an important role in the regulation of a variety of physiological processes and thus is regarded as a promising pharmaceutical agent. Nevertheless, therapeutic applications of CO are severely hampered by the difficulty of the delivery of controlled amounts of CO to biological targets. To address this deficiency, we present a spatiotemporally controllable CO-releasing platform (designated as Neu-MnO₂/Fla) for synergistic anti-inflammation. With the assistance of neutrophil membrane coating, Neu-MnO₂/Fla can target to inflammatory sites. Subsequently, excess H₂O₂ at the inflamed tissues can be decomposed into oxygen because of MnO₂ as nanozymes possessing catalase (CAT) activity, which not only relieves oxidative stress but also achieves in situ rapid photo-induced CO release. The in vitro and in vivo results indicate our CO-releasing platform exhibits a strong synergistic anti-inflammatory effect. Our work will shed light on targeted CO release to avoid side effects of therapeutic applications of CO.