Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Synthesis and Regulation of Thyroid Hormones

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Sex-related differences in pathological characteristics of colorectal cancer: a retrospective study.

Discover oncology·2026

Same author

High-accuracy QSPR models for azeotropic property prediction of binary aromatic hydrocarbon mixtures: a genetic function approximation approach.

Journal of molecular modeling·2026

Same author

NG25 Enhances Anti-Tumor Immunity in <i>KRAS</i>-Mutant Colorectal Cancer.

OncoTargets and therapy·2026

Same author

MS275 induces tumor immunosuppression by upregulating PD-L1 and enhances the efficacy of anti-PD-1 immunotherapy in colorectal cancer.

Cancer immunology, immunotherapy : CII·2025

Same author

SNORD80-guided 2'-O-methylation stabilizes the lncRNA GAS5 to regulate cellular stress responses.

Proceedings of the National Academy of Sciences of the United States of America·2025

Same author

[Preliminary Study of the Role of INPP4B in Promoting Colorectal Cancer Metastasis and the Mechanisms Involved].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition·2024

Search research articles

Related Experiment Video

Updated: Dec 9, 2025

An Ex vivo Culture System to Study Thyroid Development

An Ex vivo Culture System to Study Thyroid Development

Published on: June 6, 2014

Immunohistochemical basigin expression level in thyroid cancer tissues.

Wan-Ping Guo¹, Deng Tang¹, Yu-Yan Pang¹

¹Department of Pathology, First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, 530021, Guangxi Zhuang Autonomous Region, People's Republic of China.

World Journal of Surgical Oncology

|September 6, 2020

Summary

Basigin (BSG) expression is elevated in thyroid cancer (TC), correlating with tumor progression. This suggests BSG influences extracellular matrix interactions, impacting TC development and metastasis.

Keywords:

Basigin RNA-sequencing Thyroid cancer Thyroid papillary carcinoma Tissue microarray

More Related Videos

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Published on: July 31, 2017

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Published on: June 14, 2019

Related Experiment Videos

Last Updated: Dec 9, 2025

An Ex vivo Culture System to Study Thyroid Development

An Ex vivo Culture System to Study Thyroid Development

Published on: June 6, 2014

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Published on: July 31, 2017

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis

Published on: June 14, 2019

Area of Science:

Oncology
Molecular Biology
Genetics

Background:

Thyroid cancer (TC) is the most common endocrine malignancy.
Basigin (BSG) is implicated in tumor invasion, metastasis, and angiogenesis.

Purpose of the Study:

To investigate changes in BSG expression in thyroid cancer.
To explore the underlying mechanisms of BSG's role in TC.

Main Methods:

Analyzed BSG expression using immunohistochemistry (IHC), RNA-sequencing (RNA-seq), and microarrays.
Performed integrated analysis of 17 independent datasets (1182 TC cases, 437 controls).
Conducted Gene Ontology (GO) and KEGG pathway analyses on BSG co-expressed genes and differentially expressed genes (DEGs).

Main Results:

BSG protein levels were significantly higher in TC tissues.
Meta-analysis confirmed elevated BSG expression in TC (SMD=0.39, p<0.0001).
BSG co-expressed genes were enriched in extracellular matrix (ECM), cell adhesion, and cell-cell interaction pathways; nine hub genes were upregulated in TC.

Conclusions:

BSG expression is closely correlated with thyroid cancer progression.
BSG may influence TC through modulation of ECM, cell adhesion, and cell-cell interactions.