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AD8 patient-informant discrepancy predicts insight and cognitive impairment in Alzheimer's disease
Amanda Denny1, Katie Bartley1, Sean Edwards1
1Florida Institute of Technology, School of Psychology, Melbourne, FL, USA.
Abstract:
This study aimed to improve understanding of insight among individuals with Alzheimer's disease using patient and informant ratings of impairment on the AD8. Retrospective cohort data were used from 540 patients with a mean age of 81.1 (SD = 6.57). Informant AD8s were inversely related to patients' Montreal Cognitive Assessment (MoCA) scores (r = -.20, p < .001), while patient AD8s were not. Meanwhile, those with greater patient-informant AD8 discrepancies (suggesting low insight) endorsed fewer cognitive items on the Geriatric Depression Scale (GDS). Those with greater AD8 discrepancies also had significantly lower MoCA scores. Ultimately, the informant AD8 alone appears useful for identifying patients' degree of cognitive decline. However, when used in combination with the patient AD8 to calculate a discrepancy score, patients' degree of cognitive decline and level of insight can be better ascertained.
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