Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

HLA-DR2, a marker for class I antigen sensitization.

J M Kreisler1, M C Rementeria, R de Pablo

  • 1Department of Immunology, Clinica Puerta de Hierro, Madrid, Spain.

Transplantation
|June 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characteristics of Asthma Patients Admitted to the Intensive Care Unit of a Tertiary University Hospital in Madrid, Spain: A 5-Year Experience.

Journal of investigational allergology & clinical immunology·2024
Same author

Reply: Pulmonary aspergillosis in the Intensive Care Unit. An underdiagnosed disease? Active search protocol for pulmonary aspergillosis associated with COVID-19 pneumonia.

Medicina intensiva·2023
Same author

Feasibility of a New Model of Care for Allogeneic Stem Cell Transplantation Recipients Facilitated by eHealth: The MY-Medula Pilot Study.

Transplantation and cellular therapy·2023
Same author

How and when should a CO<sub>2</sub> removal device be used?

Medicina intensiva·2022
Same author

The value of the intensivist in the intensive care unit.

Medicina intensiva·2022
Same author

Should we abandon target temperature management at 33°C in post cardiac arrest patients?

Medicina intensiva·2022

The HLA-DR2 phenotype is linked to higher immune responsiveness in hemodialysis patients and kidney transplant recipients. This finding suggests DR2 influences transfusion sensitization and graft survival, impacting patient outcomes.

Area of Science:

  • Immunogenetics
  • Transplantation immunology

Background:

  • Human Leukocyte Antigen (HLA) compatibility is crucial for successful organ transplantation and managing transfusion reactions.
  • The HLA-DR2 phenotype has been investigated for its potential role in immune responses, but its specific impact on transfusion sensitization and renal transplant outcomes requires further elucidation.

Purpose of the Study:

  • To investigate the association between the HLA-DR2 phenotype and immune responsiveness in hemodialysis patients undergoing transfusions.
  • To evaluate the impact of the HLA-DR2 phenotype on graft survival in cadaver-donor renal transplant recipients.

Main Methods:

  • Analysis of 423 hemodialysis patients and 461 cadaver-donor renal transplants.
  • Assessment of panel reactive antibodies (PRA) to determine responder and non-responder groups.

Related Experiment Videos

  • Statistical analyses including stepwise logistic regression and multivariant discriminant analysis.

    • Main Results:

    • HLA-DR2 frequency was significantly higher in transfusion responders (36%) versus non-responders (19%).
    • DR2+ patients exhibited twice the rate of hypersensitization compared to DR2- patients.
    • Cadaver-donor renal transplants had significantly lower graft survival in DR2+ recipients, even with class I antigen mismatches.

    Conclusions:

    • The HLA-DR2 phenotype is associated with increased immune responsiveness and transfusion sensitization.
    • DR2 positivity negatively impacts renal allograft survival.
    • HLA-DR2 is a significant risk factor for transfusion sensitization and may influence immune responses to class I antigens.