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Updated: Dec 9, 2025

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
Published on: October 21, 2022
Survival of penetrating keratoplasty: a claims-based longitudinal analysis
Sumayya Ahmad1, Janek Klawe2, Canan Asli Utine3
1Icahn School of Medicine of Mount Sinai, New York, NY.
Objectives:
To report real-world long-term survival of primary penetrating keratoplasty (PK) in the United States and analyze risk factors associated with failure.
Design:
Retrospective longitudinal cohort study using a large commercial insurance database.
Participants:
Ten million patients enrolled in the database from 2011 to 2017 were identified using Current Procedural Terminology codes for PK.
Methods:
Kaplan-Meier survival analysis was performed to determine failure rate and risk factors impacting graft outcomes.
Results:
Five hundred and ninety-six primary PKs were identified. The 3-year survival was 78% (confidence interval [CI]: 73%-82%), 5-year survival was 76% (CI: 70%-80%), and 7-year survival was 73% (CI: 66%-79%).
Conclusion:
This study demonstrated a significantly lower 5-year success rate for primary PK performed for all causes than previously published case series in the United States.
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