Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

309
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
309
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

5.0K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.0K
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

970
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
970
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

666
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
666
Taste Buds and Receptors01:20

Taste Buds and Receptors

4.2K
Gustation, or the sense of taste, is intrinsically linked to the anatomical structures located on the tongue. This organ's surface, along with the entirety of the oral cavity, is adorned with stratified squamous epithelium. Evident on the tongue are elevated structures known as papillae (singular = papilla), which house the mechanisms for the transduction of gustatory stimuli. Four distinct types of papillae exist, each identified by their unique morphological attributes: the circumvallate,...
4.2K
Stress and Mental Health01:30

Stress and Mental Health

387
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
387

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Itch Relief and Quality-of-Life Improvement with Abrocitinib and Dupilumab in Patients with Moderate-to-Severe Atopic Dermatitis: A Post Hoc Analysis of JADE COMPARE and JADE DARE.

American journal of clinical dermatology·2026
Same author

Corticosteroid-Associated Adverse Events in Chronic Spontaneous Urticaria: A US Claims Data Study.

Dermatology and therapy·2026
Same author

Association of morbid obesity with atopic dermatitis differs by race and sex in a dermatology clinic cohort.

Journal of the American Academy of Dermatology·2026
Same author

Sphenopalatine Ganglion Radiofrequency Ablation for Severe Facial Rosacea Manifestations.

Pain practice : the official journal of World Institute of Pain·2026
Same author

Correction: Dupilumab Reduces Pruritus in Clinically Distinct Dermatologic Diseases: Data from Clinical Trials on Atopic Dermatitis, Prurigo Nodularis, and Chronic Spontaneous Urticaria.

Dermatology and therapy·2026
Same author

Efficacy of Remibrutinib versus Dupilumab at Early Timepoints in Chronic Spontaneous Urticaria: US Phase 3b Study Design (RECLAIM).

Dermatology and therapy·2026

Related Experiment Video

Updated: Dec 9, 2025

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
04:59

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors

Published on: September 27, 2019

12.8K

Substance use disorders and chronic itch.

Zoe M Lipman1, Gil Yosipovitch1

  • 1Dr Phillip Frost Department of Dermatology and Miami Itch Center, University of Miami, Miami, Florida.

Journal of the American Academy of Dermatology
|September 6, 2020
PubMed
Summary

Chronic pruritus, or persistent itch, can signal an underlying substance use disorder. Neurologic pathways for addiction and itch overlap, particularly involving dopamine and opioid receptors, necessitating dermatologic investigation of substance use.

Keywords:
CNS stimulantsaddictionamphetaminescocainedelusions of infestationitchopioidspruritussubstance use

More Related Videos

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

1.3K
A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

4.5K

Related Experiment Videos

Last Updated: Dec 9, 2025

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
04:59

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors

Published on: September 27, 2019

12.8K
Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

1.3K
A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

4.5K

Area of Science:

  • Neurology
  • Dermatology
  • Addiction Medicine

Background:

  • Chronic pruritus is a dermatologic symptom linked to substance use disorders.
  • Addiction and chronic itch share overlapping neurologic mechanisms, including dopaminergic reward circuits and opioid receptor imbalances.

Purpose of the Study:

  • To explore the connection between substance use disorders and chronic pruritus.
  • To highlight the importance of considering substance use in patients with unexplained chronic itch.

Main Methods:

  • Review of recent literature on the neurobiological underpinnings of addiction and pruritus.
  • Analysis of clinical presentations of pruritus in relation to specific substance use (opioids, CNS stimulants).

Main Results:

  • Opioid users commonly experience generalized pruritus.
  • Central nervous system stimulant users (e.g., cocaine, MDMA, ADHD medications) often report formication or delusional parasitosis.
  • Shared neurobiological pathways (dopamine, mu/kappa opioid receptors) link substance use, addiction, and pruritus.

Conclusions:

  • Dermatologists must consider substance use disorders in patients presenting with chronic pruritus.
  • Investigating substance use is crucial for effective management of these patients.
  • Understanding shared neurologic mechanisms can improve diagnosis and treatment of both conditions.