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CaproGlu: Multifunctional tissue adhesive platform.

Ivan Djordjevic1, Oleksandr Pokholenko1, Ankur Harish Shah1

  • 1School of Materials Science and Engineering, Nanyang Technological University, 639798, Singapore.

Biomaterials
|September 6, 2020
PubMed
Summary

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This summary is machine-generated.

A novel synthetic biomaterial, CaproGlu, offers a versatile solution for tissue repair. This food-grade adhesive bonds wet tissues rapidly using UV activation, overcoming limitations of existing bioadhesives.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Surgical Innovation

Background:

  • Existing tissue adhesives often have limitations, including reliance on specific crosslinking chemistries, poor performance on wet tissues, and potential for adverse reactions.
  • There is a clinical need for a strong, elastomeric tissue adhesive that is versatile, stable, and easy to use.

Purpose of the Study:

  • To develop a novel synthetic biomaterial for tissue mending that overcomes the drawbacks of current bioadhesives.
  • To create a multipurpose platform for tissue repair with enhanced adhesive properties on wet substrates.

Main Methods:

  • A food-grade polycaprolactone was functionalized with carbene precursors (diazirines) to create CaproGlu, a low-viscosity, VOC-free prepolymer.
  • CaproGlu was activated using low-energy UVA light (365 nm), inducing carbene diradical formation for rapid crosslinking of tissue surfaces.
Keywords:
BioadhesiveDiazirineDiazoalkanePolycaprolactoneUVA

Related Experiment Videos

  • The material's properties, including shelf stability, sterilization compatibility (gamma), and adhesion on wet tissues, were evaluated.

    • Main Results:

    • CaproGlu demonstrated rapid liquid-to-biorubber transition within seconds of UVA activation, forming a strong bond on wet tissue surfaces.
    • The activated diazirine groups effectively crosslinked all amino acids, a capability not limited by the presence of water or solvents.
    • The biomaterial exhibited exceptional shelf stability and maintained its properties after gamma sterilization.

    Conclusions:

    • CaproGlu represents a novel synthetic biomaterial with unique carbene-based crosslinking for tissue adhesion.
    • Its rapid curing, strong wet-tissue bonding, and versatility make it a promising candidate for various clinical applications, including vascular anastomosis and muscle repair.
    • The material's stability and ease of use offer a significant advancement over existing tissue adhesives.