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Updated: Dec 9, 2025

Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
ADAMTS9-AS2 and CADM2 expression and association with the prognosis in esophageal squamous cell carcinoma
Fang-Fang Shen1,2, Fan Zhang2, Hai-Jun Yang3
1Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Abstract:
Background: We investigated whether ADAMTS9-AS2 and CADM2 were related to esophageal squamous cell carcinoma (ESCC). Methodology: ESCC microarray datasets and reverse transcriptase qualitative PCR were used to analyze ADAMTS9-AS2 and CADM2 expression. Results: The GSE120356 and GSE33810 datasets identified ADAMTS9-AS2 and CADM2 as the candidates and ADAMTS9-AS2 and CADM2 expression was downregulated in ESCC. ADAMTS9-AS2 and CADM2 were positively correlated with ESCC. ADAMTS9-AS2 and CADM2 expression could discriminate ESCC from normal tissue. Five-year overall survival was shorter in underexpressed ADAMTS9-AS2 patients, and CADM2 expression level was related to 5-year overall survival. ADAMTS9-AS2 and CADM2 expression were independent prognosis indicators in ESCC patients. Conclusion: Our findings shed new light on the clinical significance of ADAMTS9-AS2 and CADM2 in ESCC carcinogenesis.
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