Related Experiment Video
Updated: Dec 9, 2025
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Low high-density lipoprotein level is correlated with the severity of COVID-19 patients: an observational study
Guyi Wang1, Quan Zhang2, Xianmei Zhao3
1Department of Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Insights
COVID-19 patients exhibit lower blood lipid levels, particularly high-density lipoprotein cholesterol (HDL-C). Low HDL-C levels in these patients are associated with an increased risk of developing severe COVID-19 outcomes.
Area of Science:
- Cardiology
- Infectious Diseases
- Biochemistry
Background:
- Coronavirus disease 2019 (COVID-19) is a global health concern.
- Understanding the clinical characteristics of COVID-19 patients is crucial for prognosis.
- Blood lipid profiles may play a role in disease severity and outcomes.
Purpose of the Study:
- To investigate blood lipid levels in COVID-19 patients.
- To determine the association between lipid profiles and COVID-19 prognosis.
- To analyze the correlation between high-density lipoprotein cholesterol (HDL-C) and COVID-19 severity.
Main Methods:
- Retrospective clinical analysis of 228 adult COVID-19 patients.
- Comparison with 1140 age- and gender-matched healthy controls.
- Statistical analysis including Mann-Whitney test, Kaplan-Meier curves, and Cox regression for HDL-C and COVID-19 severity.
Main Results:
- COVID-19 patients showed significantly lower levels of total cholesterol, triglyceride, LDL-C, and HDL-C compared to controls.
- Severe COVID-19 cases had lower HDL-C levels than non-severe cases.
- Low HDL-C was linked to higher C-reactive protein levels and a greater proportion of severe events, independent of other factors.
Conclusions:
- COVID-19 is associated with dyslipidemia, characterized by lower HDL-C levels.
- Low HDL-C in COVID-19 patients is a significant predictor of increased risk for severe disease progression.
- Monitoring HDL-C may aid in assessing COVID-19 patient prognosis.
Background:
The purpose of the study is to describe the blood lipid levels of patients diagnosed with coronavirus disease 2019 (COVID-19) and to analyze the correlation between blood lipid levels and the prognosis of COVID-19 patients.
Methods:
In the clinical retrospective analysis, a total of 228 adults infected with COVID-19 were enrolled between January 17, 2020 and March 14, 2020, in Changsha, China. One thousand one hundred and forty healthy participants with matched age and gender were used as control. Median with interquartile range and Mann-Whitney test were adopted to describe and analyze clinical data. The Kaplan-Meier (KM) curve and Cox regression analysis were used to analyze the correlation between high-density lipoprotein cholesterol (HDL-C) and the severity of COVID-19.
Results:
Compared with control, COVID-19 patients showed significantly lower levels of total cholesterol (TC) [median, 3.76 vs 4.65 mmol/L, P = 0.031], triglyceride [median, 1.08 vs 1.21 mmol/L, P < 0.001], low-density lipoprotein cholesterol (LDL-C) [median, 2.63 vs 2.83 mmol/L, P < 0.001], and HDL-C [median, 0.78 vs 1.37 mmol/L, P < 0.001], while compared with non-severe patients, severe COVID-19 patients only presented lower levels of HDL-C [median, 0.69 vs 0.79 mmol/L, P = 0.032]. In comparison with patients with high HDL-C, patients with low HDL-C showed a higher proportion of male (69.57% vs 45.60%, P = 0.004), higher levels of C-reactive protein (CRP) (median, 27.83 vs 12.56 mg/L, P < 0.001) and higher proportion of severe events (36.96% vs 14.84%, P = 0.001). Moreover, patients with low HDL-C at admission showed a higher risk of developing severe events compared with those with high HDL-C (Log Rank P = 0.009). After adjusting for age, gender and underlying diseases, they still had elevated possibility of developing severe cases than those with high HDL-C (HR 2.827, 95% CI 1.190-6.714, P = 0.019).
Conclusions:
HDL-C level was lower in COVID-19 adult patients, and low HDL-C in COVID-19 patients was correlated with a higher risk of developing severe events.
More Related Videos
Related Concept Videos
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
01:26Coronary Artery Disease IV: Preventive Measures
01:30Coronary Artery Disease I: Introduction
01:29Cholesterol: Significance and Regulation
Considering cholesterol and...
01:20Lipid-Lowering Drugs: Statins and Miscellaneous Agents
01:30Acute Coronary Syndrome III: Diagnostic Studies