Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...

Pharmacokinetics in Pediatric Patients: Drug Metabolism

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...

Kidney Transplant II: Surgical Procedure

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Factors associated with variation in treatment of the distal radioulnar joint after plate fixation of distal radial fractures.

The Journal of hand surgery, European volume·2026

Same author

Clinical safety and regenerative potential of a purified exosome product in treating skin graft donor sites: A phase 1b trial.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2026

Same author

Analysis of Functional Outcomes and Donor Site Morbidity Following Fibula Flap Harvest in the Skeletally Immature Patient Population.

Plastic and reconstructive surgery·2026

Same author

The 2026 American Association for Thoracic Surgery (AATS) expert consensus document: Surgical management of primary chest wall malignancies.

The Journal of thoracic and cardiovascular surgery·2026

Same author

Intra-Articular Purified Exosome Product and Hyaluronan Attenuate Osteoarthritis Progression in a Minimally Invasive Turkey Model.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2026

Same author

"Do as I say and not as I do: Surgical critical care program directors shape the future" authors' response to the Letter to the Editor entitled: "Artificial intelligence literacy and infectious diseases competency: Essential considerations for future revisions of the surgical critical care curriculum".

The journal of trauma and acute care surgery·2026

Same journal

Lower-Extremity Reconstruction: Principles, Progress, and Perspectives.

Clinics in plastic surgery·2026

Same journal

Pediatric.

Clinics in plastic surgery·2026

Same journal

Lower Extremity Reconstruction in Acute Burns.

Clinics in plastic surgery·2026

Same journal

Chronic Lower Extremity Wounds: Updates on Lower Extremity Reconstruction in Clinics in Plastic Surgery.

Clinics in plastic surgery·2026

Same journal

Updates in Lower Extremity Reconstruction: Post Sarcoma.

Clinics in plastic surgery·2026

Same journal

Fillet Flaps for Lower Extremity Salvage.

Clinics in plastic surgery·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Dec 9, 2025

Step By Step: Microsurgical training method combining two nonliving animal models

Step By Step: Microsurgical training method combining two nonliving animal models

Published on: May 9, 2015

Pediatric Microsurgery: A Global Overview.

Ali Izadpanah¹, Steven L Moran²

¹Department of Orthopedic Surgery, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.

Clinics in Plastic Surgery

|September 7, 2020

Summary

This summary is machine-generated.

Free tissue transfer is a reliable microsurgical technique for pediatric reconstruction. It effectively manages soft tissue and bony defects in a single stage, offering an advantage over traditional methods.

Keywords:

Children Free tissue transfer Microsurgery Pediatric

More Related Videos

Microvascular Decompression: Salient Surgical Principles and Technical Nuances

Microvascular Decompression: Salient Surgical Principles and Technical Nuances

Published on: July 5, 2011

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

Related Experiment Videos

Last Updated: Dec 9, 2025

Step By Step: Microsurgical training method combining two nonliving animal models

Step By Step: Microsurgical training method combining two nonliving animal models

Published on: May 9, 2015

Microvascular Decompression: Salient Surgical Principles and Technical Nuances

Microvascular Decompression: Salient Surgical Principles and Technical Nuances

Published on: July 5, 2011

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

Area of Science:

Plastic Surgery
Pediatric Microsurgery
Reconstructive Surgery

Background:

Microsurgical expertise has advanced, enabling the use of smaller, refined flaps.
Free tissue transfer is increasingly utilized for pediatric soft tissue and bony defects.
Pediatric microsurgery has demonstrated technical feasibility and reliability over the past 20 years.

Purpose of the Study:

To review the current advancements and applications of pediatric microsurgery.
To highlight the benefits of free tissue transfer in pediatric reconstructive surgery.

Main Methods:

Review of current literature and techniques in pediatric microsurgery.
Analysis of the application of free tissue transfer in managing pediatric defects.

Main Results:

Free tissue transfer offers a single-stage solution for complex pediatric defects.
This technique avoids historical treatments like skin grafting, tissue expansion, and pedicled flaps.
The procedure is technically feasible and reliable for pediatric patients.

Conclusions:

Free tissue transfer represents the state-of-the-art in pediatric microsurgery.
It provides an effective and efficient method for reconstructing pediatric soft tissue and bony defects.